Whole genome sequencing (WGS) in tuberculosis is an alternative to the WHO probe-based method whose main function is to detect drug resistance, genetic diversity and changes in the transmission dynamics of Mycobacterium tuberculosis complex which is the cause of tuberculosis. According to research by Butov et al., (2016) showed that a group of people are susceptible to pulmonary TB M infection and become sick with pulmonary TB (5-10%) or become drug-resistant pulmonary TB. Genetic patterns that cause deficiencies in the IL-12 and IFN-γ pathways, STAT1, IL-17F polymorphisms, are thought to be more susceptible to infection and become sick with pulmonary tuberculosis. However, the contribution of this polymorphism to the course of tuberculosis is still being studied further. Based on data from the TB Sub-Directorate, 2021, it was stated that the highest estimated cases of TB were in West Java.

 Therefore, a new breakthrough is needed that changes the paradigm in diagnosis and therapy. The existence of a national registry of M.Tb genome mutations obtained from WGS examinations will be big data that can be the basis for national TB treatment policies in the context of eliminating TB by 2030.