On June 23 2021, WHO showed data that 3,880,450 deaths had been reported in 224 countries caused by the COVID-19 pandemic. Around 250 vaccine candidates for the SARS-CoV-2 virus are being developed in the world including mRNA vaccines, viral vector vaccines, autologous vaccines with dendritic cells, inactivated virus vaccines, etc. In terms of safety, mRNA vaccines do not pose a risk of infection or mutation because there is no interaction with the genome. The mRNA vaccine has good stability and accurate expression of the target antigen protein. Production of mRNA vaccines using in vitro transcription techniques also provides production results in larger scales at lower costs.